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Obesity is a risk factor for diseases including type 2 diabetes mellitus T2DM and cardiovascular disorders.
Diabetes itself contributes to cardiac damage. Thus, studying cardiovascular events and establishing therapeutic intervention in the period of type T2DM onset and manifestation are of highest importance.
Mitochondrial dysfunction is one of the pathophysiological mechanisms leading to impaired cardiac function. These mice were maintained on a high-fat diet HFD without carbohydrates for 13 weeks followed by 4 week HFD with carbohydrates.
We determined cardiac phenotypes and mitochondrial function as well as cardiomyocyte signaling in this model.
This is the first report demonstrating that the cardiac phenotype in male diabetic NZO mice is associated with impaired cardiac energy function and signaling events. The number of T2DM patients is expanding every year 1. Diabetes is characterized by high blood glucose, either because the body cannot produce enough insulin or is unable to use it effectively, consequently leading to insulin resistance or deficiency 2.